ZOLEDRONATE INHIBITS FIBROBLASTS’ PROLIFERATION AND ACTIVATION VIA TARGETING TGF-Β SIGNALING PATHWAY


Spatial dynamics of CD39+CD8+ exhausted T cell reveal tertiary lymphoid structures-mediated response to PD-1 blockade in esophageal cancer

Abstract Despite the success of immune checkpoint blockade (ICB) therapy for esophageal squamous cell cancer, the key immune cell populations that affect ICB efficacy remain unclear.Here, imaging mass cytometry of tumor tissues from ICB-treated patients identifies a distinct cell population of CD39+PD-1+CD8+ T cells, specifically the TCF1+ subset,

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Sinus lifting before Le Fort I maxillary osteotomy: a suitable method for oral rehabilitation of edentulous patients with skelettal class-III conditions: review of the literature and report of a case

Abstract Background Functional rehabilitation of patients afflicted with severe mandibular and maxillary alveolar atrophy might be challenging especially in malformed patients.Methods Treatment planning using sinus lifting and implant placement before Le Fort I att nighthawk hotspot maxillary osteotomy in a patient with severe mandibular and poster

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